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KMID : 0616120070380030263
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 3 p.263 ~ p.269
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Phenolic Compounds from the Leaves of Nelumbo nucifera Showing DPPH Radical Scavenging Effect
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Park Chan-Hum
Song Kyung-Sik
Park Jong-Cheol
Hur Jong-Moon
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Abstract
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Nelumbo nucifera (Nymphaeaceae) has been widely used in a traditional oriental medicine to treat bleeding, fever, diarrhea, hemorrhoid, sunstroke, dysentery and dizziness. The leaves of this plant were refluxed with methanol, and then fractionated with organic solvents to screen the antioxidant activity using DPPH radical. Ethyl acetate and n-butanol fractions showed good DPPH radical scavenging effects and were carried out column chromatographies to isolate nine compounds. Their chemical structures were characterized as p-hydroxybenzoic acid (1), uracil (2), luteolin (3), quercetin 3-O-β-D-glucopyranoside (4), rhamnetin 3-O-β-D-glucopyranoside (5), isorhamnetin 3-O-β-D-glucopyranoside (6), quercetin 3-O-β-D-glucuropyranoside (7), quercetin 3-O-β-D-xylofuranosyl(1→2)-β-D-galactopyranoside (8), and adenine (9) by comparison NMR spectral data and with those in references. Compounds 1, 2, 5 and 9 were firstly isolated from this plant. Compounds 1, 3 and 4 showed potent DPPH radical scavenging activity. Especially, compound 3, luteolin showed the higher effect than ascorbic acid used as a positive control.
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KEYWORD
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Nelumbo nucifera, flavonoid, luteolin, DPPH
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